THE TRUTH IN SCIENTIFIC TERMS
How DuraStem Works
DuraStem supports stronger, fuller looking hair right from the root.
DuraStem combines carefully selected botanicals and clinically studied ingredients to nourish your scalp and help maintain the appearance of healthy, thicker-looking hair.
This formula is designed to create the optimal environment for hair that looks its best—starting at the source: your scalp.
Clinically Backed, Botanically Powered.
Adenosine
Clinically studied to support the natural hair cycle, adenosine helps hair look denser and fuller by keeping strands in their active phase.
Caffeine
Energizes the scalp and helps hair appear thicker. Caffeine may also help protect follicles from environmental stressors.
Biotin + Zinc Glycinate
These essential nutrients help support keratin structure, improve hair strength, and promote scalp wellness. Zinc glycinate is a highly absorbable form of zinc that also helps reduce buildup and excess oil.
Vitamin E (Tocopherol)
A potent antioxidant that protects the scalp from oxidative stress and helps maintain a healthy skin barrier.
Rooted in Nature
Amla Extract
Rich in antioxidants and vitamin C, amla has been used for centuries to help soothe the scalp and support shiny, manageable hair.
Horsetail Extract
Naturally high in silica, horsetail helps hair feel stronger and supports overall scalp balance.
Real Results, Naturally
DuraStem works with your body’s natural processes. By focusing on scalp nourishment, follicle support, and antioxidant defense, this formula helps improve the appearance and feel of thinning hair over time.
SCIENTIFIC REVIEW: DuraStem Ingredients
1. Adenosine
Scientific Support:
Studies in both male and female pattern hair loss have shown topical adenosine to be effective in increasing hair thickness and density.
Thought to stimulate vascular endothelial growth factor (VEGF) and promote the anagen (growth) phaseof the hair cycle.
🧪 Study: "Efficacy of adenosine-containing topical hair lotion in Japanese men with androgenetic alopecia"(Takahashi et al., 2005, Int J Cosmet Sci)
https://onlinelibrary.wiley.com/doi/10.1111/j.1346-8138.2008.00564.x
https://pubmed.ncbi.nlm.nih.gov/25925959/
2. Biotin (Vitamin B7)
Essential for keratin production, and biotin deficiency can lead to hair thinning.
Supplementation only helps if there's a deficiency; no strong evidence that it improves hair in healthy people.
🧪 Study: A systematic review (Patel et al., 2017, Skin Appendage Disord) noted efficacy only in deficient individuals.
5. Zinc Glycinate
Supports follicular health & oil gland regulation
Zinc plays a key role in protein synthesis and cell growth.
Glycinate form is highly bioavailable.
Zinc deficiency is linked with alopecia and seborrheic dermatitis.
🧪 Study: "Zinc and skin disorders" (Dreno et al., 2013)
6. Vitamin E (Tocopherol)
Antioxidant that may reduce oxidative stress on scalp
Helps protect hair follicles from oxidative damage and may improve scalp circulation.
One study found that tocotrienol (a form of vitamin E) improved hair count over 8 months.
🧪 Study: Beoy et al., 2010 (Tocotrienol supplementation in hair loss)
7. Caffeine
Topically penetrates and stimulates hair follicles
Inhibits phosphodiesterase, increases cAMP, and may counteract DHT effects in androgenetic alopecia.
Shown to promote hair shaft elongation and stimulate growth in vitro.
🧪 Study: Fischer et al., 2007 (British Journal of Dermatology)
Durastem doesn’t try to force results it supports the body’s own natural processes. By focusing on scalp health, follicle support, and antioxidant defense, this formula helps improve the look and feel of thinning hair over time.
The Science of Micro-needling,
Also known as derma rolling or collagen induction therapy, involves creating tiny punctures in the scalp using fine needles. This triggers the body’s natural healing mechanisms, improves blood flow, and activates hair follicle stem cells all of which support healthier, more resilient hair. Clinical Highlights Study Treatment Key FindingsDhurat et al., 2013 (Pilot RCT) Microneedling + Adenosine + Caffeine Combination significantly improved hair count, and effects lasted >8 months. Microneedling shown to be safe and effective. PMC English et al., 2022 (Systematic Review)Microneedling as adjunct to therapiesReview of 22 studies (1,127 participants) concluded microneedling enhances results when used with other treatments, across hair loss types, needle depths (0.5–2.5 mm), and session frequencies. himsSpringerLinkXu et al., 2024 (Meta-Analysis) Microneedling alone Across 12 RCTs, combining treatments yielded significantly greater improvements in hair count and thickness. Pei et al., 2024 Combined microneedling therapy demonstrated statistically significant increases in hair density and diameter with good safety profile. Wiley Online Library Gentile et al., 2022 Microneedling + LLLT (low-level laser therapy) + growth factors Among patients not responding to finasteride, this combo raised hair density by ~19 hairs/cm² over 20 weeks. MDPI Xiao et al., 2025 Microneedling + PRP or triamcinolone for alopecia areata micro-needling enhanced local PRP delivery and improved hair regrowth, including triamcinolone injections. oaepublish.com mechanistic Insight Micro-needling releases growth factors (like VEGF, PDGF), activates Wnt/β-catenin pathways, stimulates stem cells, and enhances drug delivery to follicles.
PMCMDPIWikipedia
General Review Expert commentary Micro-needling stimulates healing, collagen, and blood flow around hair follicles promoting new growth but is most effective when used with other therapies.
Very well Health Real Simple Byrdie Key Points
Effective when combined: Across multiple clinical studies, microneedling consistently boosts hair density and thickness, especially when paired with medications or other therapies.
Safe profile: Minor side effects (e.g., scalp redness) are typical; serious events are rare.
Supports follicle health: It activates growth pathways, enhances treatment absorption, and promotes stronger hair structure.
Stand-alone potential limited: Evidence for microneedling as a solo therapy—without adjuncts—is sparse and less compelling.
Personalized use matters: Treatment frequency, needle depth, and combination strategy should be tailored by a professional
CAFFEINE AND ADENOSINE
Overview:
Caffeine and adenosine are increasingly studied as non-hormonal options for hair loss recovery.
They work by stimulating scalp blood flow, boosting hair follicle metabolism, and prolonging the growth (anagen) phase. Recent clinical trials suggest they can increase hair density and reduce shedding, especially when applied topically in shampoos or lotions.
Clinical Evidence
Caffeine + Adenosine Shampoo (2024 RCT)
84 participants, 12 weeks. Shampoo with 0.4% caffeine + 0.2% adenosine increased hair density (118 ® 130 hairs/cmÇ) and reduced shedding (27 ® 18). Safe and well tolerated.
Caffeine – Systematic Review (2025)
9 clinical trials, 684 subjects. Most showed benefit in hair growth and density. Evidence quality ranged from moderate to very low. Caffeine considered safe and promising.
Adenosine – Systematic Review (2025)
7 clinical trials. Improved hair density, thickness, and reduced fine hairs. Meta-analysis suggested positive trends, though not statistically significant.
Adenosine Lotion (0.75%) RCT
6-month Japanese trial in men with androgenetic alopecia. Improved hair thickness, density, and global appearance. No adverse effects reported.
Mechanisms of Action
Caffeine: Improves scalp blood circulation, enhances follicle metabolism, extends anagen phase, may suppress DHT locally.
Adenosine: Stimulates dermal papilla cells, increases VEGF and FGF-7 expression, prolongs hair growth cycle, supports thicker hair shafts.
Summary of Findings
Ingredient Evidence Summary
Caffeine + Adenosine Combo Increases density and reduces shedding (12-week RCT).
Caffeine Alone Safe, promising; evidence quality mixed.
Adenosine Alone Improves thickness, density, and global hair appearance.
Mechanisms Boosts blood flow, metabolism, and growth factor signaling.
Conclusion:
Topical caffeine and adenosine are safe and promising approaches for hair loss recovery. They show measurable improvements in hair density and quality, but most studies are small or limited. For now, they can be
considered effective supportive options in a holistic hair restoration program.
Durastem Disclaimer:
For external use only. Avoid contact with eyes. If contact occurs, rinse thoroughly with water. Discontinue use if irritation, redness, or discomfort develops. Consult a physician before use if you have a known scalp condition, or if you are pregnant or nursing.
This product is not intended to diagnose, treat, cure, or prevent any disease, including hair loss conditions such as alopecia. Individual results will vary.
Before first use, apply a small amount to a clean area of skin and wait 24–48 hours. Do not use on broken or irritated skin.
Store in a cool, dry place away from direct sunlight. Keep out of reach of children.
By using this product, you agree that Durastem LLC is not liable for any adverse reactions, misuse, or unintended effects. Please read all ingredients carefully and consult a healthcare professional to see if DuraStem is right for you.